2-Furoyl chloride
2-Furoyl chloride
CAS: 527-69-5
Molecular Formula: C5H3ClO2
2-Furoyl chloride - Names and Identifiers
2-Furoyl chloride - Physico-chemical Properties
| Molecular Formula | C5H3ClO2 |
| Molar Mass | 130.53 |
| Density | 1.324 g/mL at 25 °C (lit.) |
| Melting Point | -2 °C (lit.) |
| Boling Point | 173-174 °C (lit.) |
| Flash Point | 185°F |
| Water Solubility | DECOMPOSES |
| Solubility | soluble in Ether,Acetone |
| Vapor Presure | 1.44mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear yellow to brown |
| Merck | 14,4310 |
| BRN | 110144 |
| Storage Condition | Store below +30°C. |
| Sensitive | Moisture Sensitive |
| Refractive Index | n20/D 1.531(lit.) |
| Physical and Chemical Properties | Colorless or light yellow liquid. Melting Point -2 °c, flash point 85 °c, boiling point 173 °c, 66 °c (1.33kPa). Soluble in ether and chloroform, in hot water and ethanol decomposition. |
2-Furoyl chloride - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | 34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3265 8/PG 2 |
| WGK Germany | 3 |
| RTECS | LT9925000 |
| FLUKA BRAND F CODES | 10-19-21 |
| TSCA | Yes |
| HS Code | 29321900 |
| Hazard Class | 8 |
| Packing Group | II |
2-Furoyl chloride - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | furanoyl chloride is an important organic synthesis intermediate, which is widely used in technical fields such as medicine and pesticides. Specifically, in the field of medicine, furanoyl chloride is a pharmaceutical intermediate of the third-generation veterinary cephalosporin ceftiofur. It is also mainly used to synthesize sulfadiazine drugs and is an important component in the synthesis of antimicrobial drugs. In terms of pesticides, furanoyl chloride is an important raw material composition of pesticides, fungicides, herbicides and other reagents. It is also an important intermediate for new pesticide products such as acaricide, acarone, and Kesaojing. |
| preparation | 1) add 112g(1mol) furoic acid and 145g(0.56mol) furanoyl chloride, 22.4g (0.22mol) triethylamine and 17.4g (0.22mol) pyridine to 1000ml tower kettle reboiler and mix them evenly; 2) Add 1.63g(0.012mol) zinc chloride to 238g(2mol) thionyl chloride for later use; 3) Add the mixed solution of thionyl chloride and zinc chloride in step 2) drop by drop into the feeding port on the rectification column; 4) Heat the reboiler to control the temperature of the reaction solution at 50 ℃, and the reaction time is The dropping time of the mixed solution of thionyl chloride and catalyst is controlled at 30min;5) After the reaction, the temperature of the reboiler is raised to 80 ℃ and the remaining thionyl chloride is distilled under reduced pressure, then continue to raise the temperature to 93°C and distill furanoyl chloride under reduced pressure; 6) Use sodium hydroxide to absorb the gas generated by the reaction. After testing, the purity of furanoyl chloride is 99.91%, the yield is 93.2%, the purity of the reaction raw material thionyl chloride is 98.2%, and the yield is 95.5%. |
| Preparation of methyl thiofurate | It is obtained by dissolving methyl mercaptan in a concentrated alkali and refluxing with furfuryl chloride [furanoyl chloride], and then washing, drying, and fractionation under reduced pressure to obtain the edible flavor methyl thiofurate. |
| use | for organic synthesis. |
| Production method | It is obtained by the reaction of 2-furanoic acid and thionyl chloride. The mixture of 2-furanoic acid and thionyl chloride was refluxed at 100 ℃ for 1h, then distilled, the excess thionyl chloride was first distilled, and then the fraction at 173-174 ℃ was collected to obtain furanoyl chloride with 79% yield. |
Last Update：2024-04-09 21:11:58
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